Drug intelligence / Profile preview

gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine

Development stage
Unknown
Modality
Small Molecules
01

Overview

gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine is a synthetic derivative of glutathione, an endogenous tripeptide (gamma-L-glutamyl-L-cysteinylglycine) crucial for cellular antioxidant defense and detoxification. In this derivative, the thiol group of the cysteine residue is modified by the attachment of a 2-iodobenzyl group. This specific chemical modification is expected to alter the compound's biological activity, potentially affecting its interaction with enzymes involved in glutathione metabolism or its role in redox regulation. While glutathione itself is a well-known antioxidant and substrate for various enzymes, this modified form is likely a research chemical or a specific probe designed to investigate particular biological pathways, possibly acting as an enzyme inhibitor or possessing altered pharmacokinetic properties compared to native glutathione.

02

Targets

GSTA4 (Glutathione S-transferase alpha 4)GSTM2 (Glutathione S-transferase Mu 2)

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